articles in refereed journals
- Legan, E.R., Liu, Y., Arce, N.A., Parker, E.T., Lollar, P., Zhang, X.F.*, and Li, R.* (2023): Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain. Blood 141(10): 1221-1232. (Featured paper, commentary by McKinnon, T.A.J. “2B or not 2B: art thou autoinhibitory?”, Blood, 141(10):1102-1103.)
- Cui, X., Zhang, X.F., and Jagota, A. (2023): Penetration of Cell Surface Glycocalyx by Enveloped Viruses is Aided by Weak Multivalent Adhesive Interaction. The Journal of Physical Chemistry B, 127, 2, 486–494.
- Kim, S., Liu, Y., Ziarnik, M., Cao, Y., Zhang, X.F.*, and Im, W.* (2023): Binding of Human ACE2 and RBD of Omicron Enhanced by Unique Interaction Patterns Among SARS-CoV-2 Variants of Concern. Journal of Computational Chemistry, 44: 594-601.
- Arce, N.A., Liu, Y., Chen W., Zhang, X.F.*, and Li, R.* (2022): Conservation and species-specific adaptation of force-dependent activation of von Willebrand factor. Journal of Thrombosis & Haemostasis, 20: 2686 – 2696.
- Seth, R., McKinnon, T.A.*, and Zhang, X.F.* (2022): Contribution of the von Willebrand Factor/ADAMTS13 Imbalance to COVID-19 Coagulopathy. AJP-Heart and Circulatory Physiology, 322: H87-H93. (Cover article of the January 2022 issue)
- Voos, K.M., Cao, W., Arce, N.A., Legan, E.R., Wang, Y., Lollar, P., Zhang, X.F.*, and Li R.* (2022): Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module. Journal of Thrombosis & Haemostasis, 20: 196-207. (Cover article of the January 2022 issue)
- Arce, N.A., Cao, W., Brown, A.K., Legan, E.R., Wilson, M.S., Berndt, M.C., Emsley, J., Zhang, X.F.*, and Li, R.* (2021): Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module. Nature Communications, 12:2360.
- Kim, S., Liu, Y., Lei, Z., Dicker, J., Cao, Y., Zhang, X.F. *, and Im, W.* (2021): Differential Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern. Journal of Chemical Theory and Computation,17:7972-7979.
- Cao, W., Kim, S., Dong, C., Hou, D., Im, W.*, and Zhang, X.F.* (2021): Biomechanical Characterization of SARS-CoV-2 Spike RBD and Human ACE2 Protein-Protein Interaction. Biophysical Journal, 120:1211-1219.
- Kania, S., Oztekin, A., Cheng, X., Zhang, X.F., and Webb, E. (2021): Flow regulated nucleation protrusion theory for collapsed polymers. Physical Review E, 104:054504.
- Nguyen, A., Kania, S., Cheng, X., Oztekin, A., Zhang, X.F., and Webb, E. (2021): Unraveling Kinetics of Collapsed Polymers in Extensional Flow. Macromolecules, 54:8259-8269.
- Wang, Y., Pisapati, A., Zhang, X.F., and Cheng, X. (2021): Recent Developments in Nanomaterial‐Based Shear‐Sensitive Drug Delivery Systems. Advanced Healthcare Materials, 2002196.
- Zhou, Y., Cao, W., Xu, Z., Zhang, X.F., and Liu, Y. (2021): Binding Kinetics of Liposome Conjugated E-selectin and P-selectin Glycoprotein Ligand-1 Measured with Atomic Force Microscopy. Colloids and Surfaces B: Biointerfaces, 207:112002.
- Kania, S., Oztekin, A., Cheng, X., Zhang, X.F., and Webb, E. (2021): Predicting pathological von Willebrand factor unraveling in elongational flow. Biophysical Journal, 120(10):1903-1915.
- Pisapati, A., Cao, W., Anderson, K.R., Holick, K.H., Whiteaker, P., Im, W., Miwa J.M.*, and Zhang, X.F.* (2021): Biophysical characterization of lynx-nicotinic receptor interactions using atomic force microscopy. FASEB Bioadvances, 3(12):1034-1042.
- Cui, X., Lapinski, N., Zhang, X.F., and Jagota, A. (2021): Length of Mucin-Like Domains Enhance Cell-Ebola Virus Adhesion by Increasing Binding Probability. Biophysical Journal, 120:781-790.
- Wang, Y., Chen, W., Zhang, W., Lee-Sundlov, M.M., Casari, C., Berndt, M.C., Lanza, F., Bergmeier, W., Hoffmeister, K.M., Zhang, X.F., and Li, R. (2021): Desialylation of O-glycans on glycoprotein Iba drives receptor signaling and platelet clearance. Haematologica, 106(1):220-229.
- O’Brien, H.E., Zhang, X.F., Sanz-Hernandez, M., Chion, A., Shapiro, S., Mobayen, G., Xu, Y., De Simone, A. Laffan, M.A., and McKinnon, T.A.J. (2021): Blocking von Willebrand factor free thiols inhibits binding to collagen under high and pathological shear stress. Journal of Thrombosis & Haemostasis, 19(2):358-369.
- Dong, C., Choi, Y.K., Lee, J., Zhang, X.F., Honerkamp-Smith, A., Göran, W., Lowe-Krentz, L.J., and Im, W. (2021): Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane. Glycobiology, 31(5):593-602. (Cover article of the May 2021 issue.)
- Cao, W., Cao, W., Zhang, W., Zheng, X.L.*, and Zhang, X.F.* (2020): Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor. Journal of Thrombosis & Haemostasis, 18(9):2169-2176.
- Wang, J., Lapinski, N., Zhang, X.F., and Jagota, A. (2020): Adhesive Contact Between Cylindrical (Ebola) and Spherical (SARS-CoV-2) Viral Particles and a Cell Membrane. Mechanics of Soft Materials, 2(1):1-9.
- Wang, H., Wang, L. Shang, Y., Tafti, S.Y., Cao, W., Ning, Z., Zhang, X.F., and Xu, X. (2020): Peak Force Visible Microscopy. Soft Matter, 16(36):8372-8379.
- Dong, C., Kem, N.R., Anderson, K.R., Zhang, X.F., Miwa, J.M., and Im, W. (2020): Dynamics and Interactions of GPI-Linked Lynx1 Protein with/without Nicotinic Acetylcholine Receptor in Membrane Bilayers. The Journal of Physical Chemistry B, 124(20):4017-4025. (Cover article of the March 2020 issue.)
- Pisapati, A.V., Wang, Y., Blauch, M.E., Wittenberg, N.J., Cheng, X., and Zhang, X.F.* (2020): Characterizing Single-Molecule Conformational Changes Under Shear Flow with Fluorescence. The Journal of Visualized Experiments, (155):e60784.
- Zhang, X.F.* and Cheng, X. (2019): Platelet mechanosensing axis. Nature Materials, 18:661-662.
- Sarkhosh, T., Zhang, X.F., Jellison, K.L., and Jedlicka, S.S. (2019): Biophysical binding of Cryptosporidium parvum oocysts to engineered substrates as a function of surface chemistry and oocyst age. Applied and environmental microbiology, 00816-19.
- Dong, C., Kania, S., Morabito, M., Zhang, X.F., Im, W., Oztekin, A., Cheng, X., and Webb, E.B. (2019): A mechano-reactive coarse-grained model of the blood-clotting agent von Willebrand factor. The Journal of Chemical Physics, 151:124905.
- Wang, Y., Morabito, M., Zhang, X.F.*, Oztekin, A., Webb, E.B., and Cheng, X.*, (2019): Shear-Induced Extensional Response Behaviors of Tethered von Willebrand Factor. Biophysical Journal, 116(11):2092-2102.
- Zhang. X.F.*, Zhang, W., Quach, M.E., Deng, W., and Li, R. (2019): Force-regulated refolding of the mechanosensory domain in platelet glycoprotein Ib-IX complex. Biophysical Journal, 116(10):1960-1969.
- Morabito, M., Usta, M., Zhang, X.F., Cheng, X., Oztekin, A., and Webb, E.B. (2019): Prediction of Sub-Monomer A2 Domain Dynamics of the von Willebrand Factor by Machine Learning Algorithm and Coarse-Grained Molecular Dynamics Simulation. Scientific Reports, 9:9037.
- Dragovich, M.A., Fortoul, N., Jagota, A., Schutt, K., Xu, Y., Sanabria, M., Moller-Tank, S., Maury, W., and Zhang. X.F.* (2019): Biomechanical characterization of TIM protein-mediated Ebola virus-host cell adhesion. Scientific Reports, 9:267.
- Morabito, M., Dong, C., Wei, W., Cheng, X., Zhang, X.F., Oztekin, A., and Webb, E.B. (2018): Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow. Biophysical Journal, 115(10):1860-1871.
- Zheng, Y., Zhang, X.F., Fu, B., and Tarbell, J.M.: (2018): The role of endothelial glycocalyx in mechanosensing and transduction. Advances in Experimental Medicine and Biology, 1097:1-27.
- Zhang, X.F., Sun, D., Song, J.W., Lipphardt, M., and Goligorsky, M.S. (2018): Endothelial cell dysfunction and glycocalyx – the vicious circle. Matrix Biology, 71-72:421-431.
- Dong, C., Lee, J., Kim, S., Lai, W., Webb, E.B., Oztekin, A., Zhang, X.F., and Im, W. (2018): Long-ranged protein-glycan interactions stabilize von Willebrand Factor A2 domain from mechanical unfolding. Scientific Reports, 8(1):16017.
- Wang, S., Wu, C., Zhang, Y., Zhong, Q., Sun, H., Cao, W., Ge, G.X., Li, G.H., Zhang, X.F.*, and Chen, J.F.* (2018): The Structural basis of chemokine-mediated switch in integrin α4β7 ligand specificity. The Journal of Cell Biology, 217(8): 2799-2812.
- Wei, W., Dong, C., Morabito, M., Cheng, X., Zhang, X.F., Oztekin, A., and Webb, E.B. (2018): Characteristics of von Willebrand Factor adhesion on collagen surface under flow. Biophysical Journal, 114(8):1816-1829.
- Quach, M.E., Dragovich, M.A., Chen, W., Syed, A.K., Cao, W., Liang, X., Deng, W., De Meyer, S., Zhu, G., Ni, He., Ware, J., Deckmyn, H., Zhang, X.F., and Li, R. (2018): Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets. Blood, 131(7):787-796.
- Song, J.W., Zullo, J.A., Lipphardt, M., Dragovich, M., Zhang X.F., Fu, B., and Goligorsky, M. (2018): Endothelial Glycocalyx – the battleground for complications of sepsis and kidney injury. Nephrology Dialysis Transplantation, 33(2):203-211.
- Bondu, V., Wu, C., Cao, W., Simons, P., Gillette, J., Zhu, J., Erb, L., Zhang, X.F.*, and Buranda, T.* (2017): Low affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection. Molecular Biology of the Cell, 28(21):2887-2903.
- Guo, X.D., Yan, C., Shi, X., Huang, M., Huang, W., Wang, Y., Pan, W., Cai, M., Li, L., Wu, W., Bai, Y., Zhang, C., Liu, Z., Wang, X., Zhang, X.F., Tang, C., Wang, H., Liu, W., Ouyang, B., Wong, C.C., Chou, J.J., Cao, Y., and Xu, C. (2017): Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor. Cell Research, 27(4):505-525.
- Song, J.W., Zullo, J.A., Liveris, D., Dragovich, M., Zhang X.F., and Goligorsky, M.S. (2017): Therapeutic Restoration of Endothelial Glycocalyx in Sepsis. The Journal of pharmacology and experimental therapeutics, 361(1):115-121.
- Dragovich, M.A., Genemaras, K., Dailey H.L., Jedlicka S., and Zhang, X.F.* (2017): Dual regulation of L-selectin-mediated leukocyte-endothelial adhesion by endothelial surface glycocalyx. Cellular and Molecular Bioengineering, 10(1):102-113.
- Deng, W., Xu, Y., Chen, W., Paul, D.S., Syed, A.K., Dragovich, M.A., Liang, X., Zakas, P., Berndt, M.C., DiPaola, J., Ware, J., Lanza, F., Doering, C.B., Bergmeier, W., Zhang, X., and Li, R. (2016): Platelet clearance via shear-induced unfolding of the mechanosensory domain in glycoprotein Ib-IX complex. Nature Communications, 7:12863.
- Dragovich, M.A., Chester, D., Fu, B., Goligorsky, M.S., and Zhang. X.F.* (2016): Mechanotransduction of endothelial glycocalyx mediates nitric oxide production by activation of TRP channels. AJP – Cell Physiology, 311(6):C846-853.
- LeBlon, C.E, Fodor, C. R., Zhang, T., Zhang, X., and Jedlicka, S.S. (2015): Correlation between in vitro expansion-related cell stiffening and differentiation potential of human mesenchymal stem cells. Differentiation, 90(1):1-15.
- Zhang, W., Deng, W., Zhou, L., Xu, Y., Yang, W., Liang, X., Wang, Y., Kulman, J.D., Zhang, X.F.*, and Li, R.* (2015): Identification of a juxtamembrane mechano-sensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex. Blood, 125:562-569. (Featured paper, comments see Ruggeri, E.M. “Platelet GPIb: sensing force and responding”, Blood, 125:423-424.)
- Fu, X., Xu, Y., Wu, C., Moy, V.T., and Zhang, X.F.* (2015): Anchorage-dependent binding of integrin I-domain to adhesion ligands. Journal of Molecular Recognition, 28:385-92.
- Ouyang, Y., Wei, W., Cheng X., Zhang, X.F., Webb, E.B. III, and Oztekin, A. (2015): Flow-induced conformational change of von Willebrand Factor multimer. Journal of Non-Newtonian Fluid Mechanics, 217:58-67.
- Zhang, W., Deng, W., Wang, Y., Zhou, L., Yang, W., Linag, X., Cho, S., Kulman, J.D., Zhang, X.F., and Li, R. (2014): Identification of the mechanosensory domain in the platelet mechanosensor GPIb-IX complex. Journal of Thrombosis and Haemostasis, 12:74-75.
- Wang, Y.Z., Chen, L., Wang, H.Y., Zhang, X., Fu, J., Xiong, X.M., and Zhang, J.X. (2014): Development of “fragility” in relaxor ferroelectrics. Journal of Applied Physics, 115:054106.
- Cao, Y., Hoeppner, L.H., Bach, S., Guangqi, E., Guo, Y., Wang, E., Wu, J., Cowley, M.J., Chang, D.K., Waddell, N., Grimmond, S.M., Biankin, A.V., Daly, R.J., Zhang, X.F., and Mukhopadhyay, D. (2013): Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial a5 integrin. Cancer Research, 73(14):4579-4590.
- Wang, Y.Z., Zhang, X.F.*, and Zhang, J.X. (2013): A “configurational entropy-loss” law for non-Arrhenius relaxation in disordered systems. Journal of Applied Physics, 113:194105.
- Wang, Y.Z., Zhang, X.F., and Zhang, J.X. (2013): New insight into the kinetic behavior of the structural formation process in agar gelation. Rheologica Acta, 52:39-48.
- Przybylowski, C., Quinn, T., Callahan, A., Kaplan, M., Golding, A., Alesi, C., Ammar, M., LeBlon, C.E, Guo, Y., Zhang, X., and Jedlicka, S.S. (2012): MC3T3 Preosteoblast Differentiation on Bone Morphogenetic Protein-2 Peptide Ormosils. The Journal of Materials Chemistry, 22:10672-10683.
- Hu, L., Fan, Z., Du, H., Ni, R., Zhang, S., Yin, K., Ye, J., Zhang, Y., Wei, X., Zhang, X., Gross, P. L., Kunapuli, S. P., and Ding, Z. (2011): BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase. Thrombosis and Haemostasis, 106: 1203-14.
- Zhang, S., Hu, L., Yu, X., Guo, Y., Zhang, Y., Niu, H., Jin, J., Bhavaraju, K., Du, H., Liu, J., Zhang, X., Kunapuli, S. P., and Ding, Z. (2010): BF0801, a novel adenine derivative, inhibits platelet activation via PDE inhibition and P2Y12 antagonism. Thrombosis and Haemostasis, 104:845-57.
- Du, D., Xu, F., Yu, L., Bao, H., Zhang, C., Lu, X., Yuan, H., Zhu, X., Zhang, X., and Chen, Z. (2010): The tight junction protein, occludin, regulates the directional migration of epithelial cells. Developmental Cell, 18:52-63.
- Kim, J., Zhang, C.-Z., Zhang, X., and Springer, T.A. (2010): A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature, 466:992-5.
- Zhang, X., Halvorsen, K., Zhang, C.Z., Wong, W.P., and Springer, T.A. (2009): Mechanoenzymatic cleavage of the ultra-large vascular protein, von Willebrand Factor. Science, 324:1330-1334. (Featured paper, comments see Gebhardt, J. C. and Rief, M. “Force Signaling in Biology”, Science, 324:1278-1280.)
- Zhang, Q., Zhou, Y., Zhang, C.Z., Zhang, X., Lu, C., and Springer, T.A. (2009): Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. PNAS, 106(23):9226-31.
Prior to 2009 - Zhang, X.*, Wojcikiewicz, E., and Moy, V.T. (2006): Dynamic adhesion of T-lymphocytes to endothelial cells revealed by atomic force microscopy. Experimental Biology and Medicine, 231:1306-12.
- Wojcikiewicz, E., Abdulreda, M.H., Zhang, X., and Moy, V.T. (2006): Force spectroscopy of LFA-1 and its ligands, ICAM-1 and ICAM-2. Biomacromolecules, 7:3188-3195.
- Zhang, X., Craig, S.E., Kirby, H., Humphries, M.J., and Moy, V.T. (2004): Molecule basis for the dynamic strength of the integrin a4β1/VCAM-1 interaction. Biophysical Journal, 87:3470-3478.
- Zhang, X., Chen, A., DeLeon, D., Li, H., Noiri, E., Moy, V.T., and Goligorsky, M.S. (2004): Atomic force microscopy measurement of leukocyte-endothelial interaction. American Journal of Physiology-Heart and Circulatory Physiology, 286:H359-367.
- Zhang, X., Bogorin D.F., and Moy, V.T. (2004): Molecular basis of the dynamic strength of the sialyl Lewis x – selectin Interaction. ChemPhysChem, 4:100-107.
- Wojcikiewicz, E., Zhang, X., and Moy, V.T. (2004). Force and compliance measurements on living cells using atomic force microscopy. Biological Procedures Online, 6:1-9.
- Zhang, X. and Moy, V.T. (2004): Intermolecular forces of leukocyte adhesion molecules. Microscopy and Microanalysis, 10:1422-1423.
- Zhang, X.* and Moy, V.T. (2003): Cooperative adhesion of ligand-receptor bonds. Biophysical Chemistry, 104:271-278.
- Wojcikiewicz, E., Zhang, X., and Moy, V.T. (2003): Contributions of molecular binding events and cellular compliance to the modulation of leukocyte adhesion. Journal of Cell Science, 116:2531-2539.
- Zhang, X., Wojcikiewicz, E., and Moy, V.T. (2002): Force spectroscopy of the Leukocyte Function-Associated Antigen-1 (LFA-1)/Intercellular Adhesion Molecule-1 (ICAM-1) interaction. Biophysical Journal, 83:2270-2279.
- Micic, M., Zheng, Y., Moy, V.T., Zhang, X., Andreanopolous, F, Hua, F.Q., and Leblanc, R.M. (2002): Comparative studies of surface topography and mechanical properties of a novel photoswitchable, biocompatible PEG-NC based hydrogel. Colloids and Surfaces B: Biointerface, 27:147-158.
- Zhang, X., Wojcikiewicz, E., and Moy, V.T. (2002). Probing single ICAM-1/LFA-1 interactions under external forces. ScientificWorldJournal, 2:41-42.
- Lui, S.L., Chan, L.Y.Y., Zhang, X., Zhu, W., Chan, T.M., Fung, P.C.W., and Lai, K.N. (2001): Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury. Nephrology, Dialysis, Transplantation, 16:1577-1582.
- Zhang, X., Li, H., Jin, H., Ebin, Z., Brodsky, S., and Goligorsky, M.S. (2000): Effects of homocysteine on endothelial nitric oxide production. American Journal of Physiology-Renal Physiology, 279:F671-678.
- Ge, Z.D., Zhang, X., Fung, P.C.W., and He, G.W. (2000): Endothelium-dependent hyperpolarization under relaxation resistant to N(G)-nitro-L-arginine (L-NNA) and indomethacin in coronary micro-arteries. Cardiovascular Research, 46:547-556.
- Kuang, Z.Q., Zhang, J.X., Zhang, X., Liang, K.F., and Fung, P.C.W. (2000): Kinetic parameters in the thermoelastic martensitic transformation of Co. Solid State Communications, 14:231-235.
- Kuang, Z.Q., Zhang, J.X., Zhang, X., Liang, K.F., and Fung, P.C.W. (2000): Scaling behaviours in the thermoelastic martensitic transformation of Co. Scripta Materialia, 42:795-799.
- Chan, K.L., Zhang, X., Fung, P.C.W, Guo, W.H., and Tam, P.K.H. (1999): Role of nitric oxide in intestinal ischaemia-reperfusion injury studied using electron paramagnetic resonance. British Journal of Surgery, 86:1427-1432.80.
- Lui, S.L., Zhang, X., Zhu, W., Lo, C.Y., Chan, T.M., Fung, C.W., and Lai, K.N. (1999): Demonstration of nitric oxide generation during renal ischemia-reperfusion injury. Transplantation Proceedings, 3:1020-1021.
Asterisk* denotes the corresponding author.
Names underlined are students/trainees of the Frank Zhang group.
Representative journal covers:




BOOK CHAPTERS
- Rico, F., Zhang, X., and Moy, V.T. (2011): Probing cellular adhesion at the single molecular level. Chapter 11 (p. 225-262) in Life at the Nanoscale: Atomic Force Microscopy of Live Cells (Yves Dufrêne, Ed.), Pan Stanford Publishing Ltd.
- Zhang, X.*, Rico F., Xu, A.J., and Moy, V.T. (2009): Atomic force microscopy of protein-protein interactions. Chapter 19 in Handbook of Single-Molecule Biophysics (Peter Hinterdorfer and Antoine van Oijen, Ed. ISBN: 978-0-387-76496-2), Springer Publishing (http://www.springerlink.com/content/q85x87x114735130/).
- Zhang, X. and Moy, V.T. (2006): Intermolecular forces of leukocyte adhesion molecules. Chapter 9 (p. 159-168) in Force Microscopy: Application in Biology and Medicine (Bhanu P. Jena and Johann Karl H. Horber, Ed.), John Wiley & Sons Inc. Press.
- Zhang, X., Wojcikiewicz, E., Abdulreda, M., Chen, A., and Moy, V.T. (2005): Probing ligand-receptor interactions with atomic force microscopy. Chapter 21 (p. 399-413) in Protein-Protein Interactions: A Molecular Cloning Manual, 2nd Edition (Erica A. Golemis and Peter D. Adams, Ed.), Cold Spring Harbor Laboratory Press.
- Zhang, X., Chen, A., Wojcikiewicz, E., and Moy, V.T. (2002): Probing ligand-receptor interactions with atomic force microscopy. Chapter 13 (p. 241-254) in Protein-Protein Interactions: A Molecular Cloning Manual (Erica A. Golemis, Ed.), Cold Spring Harbor Laboratory Press.