About Dr. Frank Zhang

Principal Investigator
Professor of Biomedical Engineering, Department of Biomedical Engineering, University of Massachusetts Amherst

Dr. Xiaohui (Frank) Zhang holds a Ph.D. in Physiology and Biophysics from the University of Miami School of Medicine, a master’s degree in Biophysics from The University of Hong Kong, and a bachelor’s degree in Physics from Sun Yat-sen University. He completed his postdoctoral training with Prof. Timothy A. Springer at Harvard Medical School. Prior to joining the faculty at the University of Massachusetts Amherst, Dr. Zhang was a professor of bioengineering at Lehigh University.

At UMass Amherst, Dr. Zhang leads a multidisciplinary team comprising bioengineers, mechanical engineers, biophysicists, and biologists. The group’s research centers around the biomechanical properties of cells and proteins, the development of novel experimental and diagnostic techniques based on single-molecule manipulation and detection methods, and their application to study cardiovascular diseases, blood clotting, tissue repair, and viral infection.

Dr. Zhang’s ongoing projects:

  1. NIH R01HL157975, “Mechanism underlying cofactor-dependent proteolysis of von Willebrand Factor”, 2/1/2022 – 1/31/2026. (MPI)
  2. NSF 2200066 “PIPP Phase 1: Dynamics of Pandemic Spread and Prevention in Indigenous Communities”, 8/1/2022 – 1/31/2024. (Senior Personnel)
  3. NIH R01HL153986, “Mechanical regulation of von Willebrand factor”, 9/1/2021 – 6/30/2025. (PI)
  4. NIH R21AI163708, “Biophysical characterization of SARS-CoV-2 spike protein – receptor interactions”, 7/6/2021 – 6/30/2023. (MPI)
  5. NSF DMR-2004475, “Bioinspired, Single-molecule Based Shear Switchable Nanomaterials”, 6/1/2020 – 5/31/2023. (Co-PI)
  6. NIH R21HL152348, “Single-cell analysis of endothelial mechanotransduction mediated by endothelial surface glycocalyx”, 5/1/2020 – 4/30/2023. (PI)
  7. NIH R01HL082808, “Structure and function of platelet glycoprotein Ib-IX-V complex”, 2/1/2020 – 11/30/2023. (Co-I)
  8. NIH R01DA043567, “Prototoxin Effects on Nicotinic Receptor Function”, 4/1/2018 – 2/28/2023. (Co-I)

The research group moved from Lehigh to the University of Massachusetts Amherst, Department of Biomedical Engineering, in September 2022.


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